ARG44495
anti-HAAO antibody
anti-HAAO antibody for ICC/IF,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes HAAO |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | HAAO |
| 抗原物种 | Human |
| 抗原 | Human HAAO recombinant protein |
| 偶联标记 | Un-conjugated |
| 別名 | HAAO; 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-HAO; 3-Hydroxyanthranilic Acid Dioxygenase; 3-Hydroxyanthranilate Oxygenase; EC 1.13.11.6; H3HAO; HAO; HAD; 3-Hydroxyanthranilic-Acid Dioxygenase; VCRL1 |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
生物信息
| 数据库连接 |
Swiss-port # P46952 Human 3-hydroxyanthranilate 3,4-dioxygenase Swiss-port # P46953 Rat 3-hydroxyanthranilate 3,4-dioxygenase |
|---|---|
| 基因名称 | HAAO |
| 全名 | 3-Hydroxyanthranilate 3,4-Dioxygenase |
| 背景介绍 | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. |
| 生物功能 | Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
| 细胞定位 | Cytoplasm |
| 预测分子量 | 33 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG44495 anti-HAAO antibody ICC/IF image
Immunofluorescence: Caco-2 stained with ARG44495 anti-HAAO antibody at 5 μg/mL dilution.
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ARG44495 anti-HAAO antibody WB image
Western blot: Rat liver stained with ARG44495 anti-HAAO antibody at 0.5 μg/mL dilution.
