ARG54853
anti-Gremlin antibody
anti-Gremlin antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Developmental Biology antibody; Signaling Transduction antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Gremlin |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Gremlin |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 147-175 (C-terminus) of Human Gremlin. |
| 偶联标记 | Un-conjugated |
| 別名 | GREMLIN; Increased in high glucose protein 2; Gremlin-1; DUP15q; DAND2; CRAC1; MPSH; CKTSF1B1; PIG2; DRM; HMPS1; DAN domain family member 2; IHG-2; HMPS; Cysteine knot superfamily 1, BMP antagonist 1; Cell proliferation-inducing gene 2 protein; C15DUPq; CRCS4; Down-regulated in Mos-transformed cells protein |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | CEM |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Grem1 |
| 全名 | gremlin 1 |
| 背景介绍 | This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010] |
| 生物功能 | Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Acts as inhibitor of monocyte chemotaxis. [UniProt] |
| 细胞定位 | Secreted. |
| 研究领域 | Developmental Biology antibody; Signaling Transduction antibody |
| 预测分子量 | 21 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG54853 anti-Gremlin antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human skeletal muscle tissue stained with ARG54853 anti-Gremlin antibody.
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ARG54853 anti-Gremlin antibody WB image
Western blot: 35 µg of CEM cell lysate stained with ARG54853 anti-Gremlin antibody.
