ARG67035
anti-Glypican 3 antibody [SQab30329]
anti-Glypican 3 antibody [SQab30329] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant rabbit Monoclonal antibody [SQab30329] recognizes Glypican 3 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30329 |
| 同位型 | IgG |
| 靶点名称 | Glypican 3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human Glypican 3 |
| 偶联标记 | Un-conjugated |
| Protein Full name | Glypican-3 |
| 別名 | GPC3, Glypican 3, OCI 5, SGBS1, SGBS, DGSX, SGB, Intestinal Protein OCI 5, Glypican Proteoglycan 3, Glypican 3, GTR2-2, MXR7, SDYS, Heparan Sulphate Proteoglycan, Secreted Glypican-3, OCI5 |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Hepatocellular carcinoma |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GPC3 |
| 全名 | Glypican 3 |
| 背景介绍 | Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009] |
| 生物功能 | Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression.Inhibits the dipeptidyl peptidase activity of DPP4. [UniProt] |
| 细胞定位 | Cell membrane, Membrane |
| 预测分子量 | 66 kDa |
| 翻译后修饰 | This processing is essential for its role in inhibition of hedgehog signaling. A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG67035 anti-Glypican 3 antibody [SQab30329] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded hepatocellular carcinoma stained with ARG67035 anti-Glypican 3 antibody [SQab30329].
