ARG67262
anti-Glutamine synthetase antibody [SQab30378]
anti-Glutamine synthetase antibody [SQab30378] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Monoclonal antibody [SQab30378] recognizes Glutamine synthetase. |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30378 |
| 同位型 | IgG |
| 靶点名称 | Glutamine synthetase |
| 抗原 | Synthetic peptide. |
| 偶联标记 | Un-conjugated |
| 別名 | GLUL; Glutamate-Ammonia Ligase; Glutamine Synthetase ; GLNS; Palmitoyltransferase GLUL; EC 6.3.1.2; GS; Glutamate-Ammonia Ligase (Glutamine Synthase); Cell Proliferation-Inducing Protein 59; Proliferation-Inducing Protein 43; Glutamate--Ammonia Ligase; Glutamate Decarboxylase; Glutamine Synthase; EC 2.3.1.225; DEE116; PIG43; PIG59 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GLUL |
| 全名 | Glutamate-Ammonia Ligase |
| 背景介绍 | The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| 生物功能 | Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2. [Uniprot] |
| 细胞定位 | Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Microsome, Mitochondrion. [Uniprot] |
| 预测分子量 | 42 kDa |
| 翻译后修饰 | Acetylation, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
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ARG67262 anti-Glutamine synthetase antibody [SQab30378] IHC-P image
Immunohistochemistry: Human Liver stained with ARG67262 anti-Glutamine synthetase antibody [SQab30378] at 1:100 dilution.
