ARG67033
anti-Gastrin antibody [SQab30315]
anti-Gastrin antibody [SQab30315] for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Recombinant rabbit Monoclonal antibody [SQab30315] recognizes Gastrin |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | SQab30315 |
| 同位型 | IgG |
| 靶点名称 | Gastrin |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human Gastrin. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Gastrin |
| 別名 | GAST, Gastrin, GAS, Preprogastrin |
应用说明
| 应用建议 |
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| 应用说明 | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Human gastric cancer |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05%BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GAST |
| 全名 | Gastrin |
| 背景介绍 | Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008] |
| 生物功能 | Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. [Uniprot] |
| 细胞定位 | Secreted |
| 预测分子量 | 16 kDa |
| 翻译后修饰 | Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific. [Uniprot] |
检测图片 (1) Click the Picture to Zoom In
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ARG67033 anti-Gastrin antibody [SQab30315] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded human gastric cancer stained with ARG67033 anti-Gastrin antibody [SQab30315].
