ARG52340
anti-GRM7 phospho (Ser862) antibody
anti-GRM7 phospho (Ser862) antibody for Western blot and Mouse,Rat
Neuroscience antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GRM7 phospho (Ser862) |
|---|---|
| 反应物种 | Ms, Rat |
| 预测物种 | Hu, Bov, Dog, NHuPrm, Zfsh |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GRM7 |
| 抗原物种 | Rat |
| 抗原 | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser862 conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | MGLU7; GPRC1G; Metabotropic glutamate receptor 7; GLUR7; mGluR7; PPP1R87; MGLUR7 |
应用说明
| 应用建议 |
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| 应用说明 | Specific for the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GRM7 |
| 全名 | glutamate receptor, metabotropic 7 |
| 背景介绍 | Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4,6,7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of serine 862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008). |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 102 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG52340 anti-GRM7 phospho (Ser862) antibody WB image
Western blot: Mouse brain lysate showing the specific immunolabeling of the ~102k mGluR7 protein phosphorylated at Ser 862 stained with ARG52340 anti-GRM7 phospho (Ser862) antibody. Immunolabeling is blocked by the phospho-peptide used as antigen.
