ARG58863
anti-GRK6 antibody
anti-GRK6 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GRK6 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GRK6 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-170 of Human GRK6 (NP_001004106.1). |
| 偶联标记 | Un-conjugated |
| 別名 | G protein-coupled receptor kinase GRK6; G protein-coupled receptor kinase 6; EC 2.7.11.16; GPRK6 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Jurkat | ||||
| 实际分子量 | 65 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O70293 Mouse G protein-coupled receptor kinase 6 Swiss-port # P43250 Human G protein-coupled receptor kinase 6 |
|---|---|
| 基因名称 | GRK6 |
| 全名 | G protein-coupled receptor kinase 6 |
| 背景介绍 | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). [UniProt] |
| 细胞定位 | Lipid-anchor, Membrane. [UniProt] |
| 预测分子量 | 66 kDa |
| 翻译后修饰 | It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58863 anti-GRK6 antibody WB image
Western blot: 25 µg of Jurkat cell lysate stained with ARG58863 anti-GRK6 antibody at 1:1000 dilution.
