ARG55272
anti-GRIK1 / GluR5 antibody
anti-GRIK1 / GluR5 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Neuroscience antibody
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GRIK1 / GluR5 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GRIK1 / GluR5 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide (15 aa) within the last 50 aa of Human GRIK1 / GluR5. |
| 偶联标记 | Un-conjugated |
| 別名 | GluR5; GluK1; GLUR5; EEA3; GluR-5; Excitatory amino acid receptor 3; Glutamate receptor ionotropic, kainate 1; EAA3; Glutamate receptor 5; GLR5 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | P815 Cell Lysate |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS and 0.02% Sodium azide |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P39086 Human Glutamate receptor ionotropic, kainate 1 |
|---|---|
| 基因名称 | GRIK1 |
| 全名 | glutamate receptor, ionotropic, kainate 1 |
| 背景介绍 | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. [UniProt] |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 104 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG55272 anti-GRIK1 / GluR5 antibody IHC-P image
Immunohistochemistry: Human brain tissue stained with ARG55272 anti-GRIK1 / GluR5 antibody at 2.5 µg/ml dilution.
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ARG55272 anti-GRIK1 / GluR5 antibody WB image
Western blot: P815 cell lysate stained with ARG55272 anti-GRIK1 / GluR5 antibody at (A) 0.5, (B) 1 and (C) 2 µg/ml dilution.
文献引用
Ultrarare Loss-of-Function Mutations in the Genes Encoding the Ionotropic Glutamate Receptors of Kainate Subtypes Associated with Schizophrenia Disrupt the Interaction with PSD95
WB / Huaman
