ARG43511
anti-GRID2 antibody
anti-GRID2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GRID2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | FACS, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GRID2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to N-terminal region of human Somatostatin. |
| 偶联标记 | Un-conjugated |
| 別名 | GRID2; Glutamate Ionotropic Receptor Delta Type Subunit 2; GluD2; Glutamate Receptor, Ionotropic, Delta 2; Glutamate Receptor Ionotropic, Delta-2; GluR Delta-2 Subunit; GluR-Delta-2; Glutamate Receptor Delta-2 Subunit; SCAR18; GLURD2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 实际分子量 | 113 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.01% Sodium azide and 4% Trehalose. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 4% Trehalose |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GRID2 |
| 全名 | Glutamate Ionotropic Receptor Delta Type Subunit 2 |
| 背景介绍 | The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014] |
| 生物功能 | Member of the ionotropic glutamate receptor family, which plays a crucial role in synaptic organization and signal transduction in the central nervous system. Although it shares structural features with ionotropic glutamate receptors, does not bind glutamate as a primary ligand. Promotes synaptogenesis and mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis of cerebellar parallel fiber-Purkinje cell (PF-PC) synapses through the NRX1B-CBLN1-GRID2 triad complex. [UniProt] |
| 细胞定位 | Cell membrane; Membrane; Postsynaptic cell membrane; Synapse. [UniProt] |
| 预测分子量 | 113 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Phosphoprotein. [UniProt] |
检测图片 (5) Click the Picture to Zoom In
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ARG43511 anti-GRID2 antibody WB image
Western blot: HL-60 stained with ARG43511 anti-GRID2 antibody at 0.5 μg/ml dilution.
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ARG43511 anti-GRID2 antibody FACS image
Flow Cytometry: U20S stained with ARG43511 anti-GRID2 antibody at 1 µg/10^6 cells dilution.
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ARG43511 anti-GRID2 antibody WB image
Western blot: Rat brain stained with ARG43511 anti-GRID2 antibody at 0.5 μg/ml dilution.
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ARG43511 anti-GRID2 antibody FACS image
Flow Cytometry: C6 stained with ARG43511 anti-GRID2 antibody at 1 µg/10^6 cells dilution.
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ARG43511 anti-GRID2 antibody WB image
Western blot: Mouse brain stained with ARG43511 anti-GRID2 antibody at 0.5 μg/ml dilution.
