ARG45072
anti-GRB2 antibody [M331]
anti-GRB2 antibody [M331] for ICC/IF,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [M331] recognizes GRB2 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IP, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | M331 |
| 同位型 | IgG1 |
| 靶点名称 | GRB2 |
| 抗原物种 | Rat |
| 抗原 | Clone (M331) was generated from a full length recombinant rat Grb2 protein. This sequence has high homology to human and mouse Grb2. |
| 偶联标记 | Un-conjugated |
| 別名 | GRB2; Growth Factor Receptor Bound Protein 2; Growth Factor Receptor-Bound Protein 2; NCKAP2; SH2/SH3 Adapter GRB2; Protein Ash; ASH; Epidermal Growth Factor Receptor-Binding Protein GRB2; Epididymis Secretory Sperm Binding Protein; Growth Factor Receptor-Bound Protein 3; Abundant SRC Homology; Adapter Protein GRB2; EGFRBP-GRB2; MSTP084; Grb3-3; MST084; HT027 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A Purified. |
| 缓冲液 | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| 稳定剂 | 50% Glycerol and 0.1 % BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GRB2 |
| 全名 | Growth Factor Receptor Bound Protein 2 |
| 背景介绍 | The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Additionally, directly recruits and later releases MRE11 at DNA damage sites during the homology-directed repair (HDR) process . [Uniprot] |
| 细胞定位 | Cytoplasm, Endosome, Golgi apparatus, Nucleus. [Uniprot] |
| 预测分子量 | 25 kDa |
| 翻译后修饰 | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation. [Uniprot] |
