ARG58933
anti-GM2A antibody
anti-GM2A antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GM2A |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Gpig |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GM2A |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the N-terminal region of Human GM2A. (within the following region: SWDNCDEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDL) |
| 偶联标记 | Un-conjugated |
| 別名 | Ganglioside GM2 activator; SAP-3; Cerebroside sulfate activator protein; GM2-AP; Sphingolipid activator protein 3 |
应用说明
| 预测反应性说明 | Predicted Homology Based On Immunogen Sequence: Guinea pig: 83% | ||||
|---|---|---|---|---|---|
| 应用建议 |
|
||||
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HeLa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | Batch dependent: 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GM2A |
| 全名 | GM2 ganglioside activator |
| 背景介绍 | This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009] |
| 生物功能 | The large binding pocket can accommodate several single chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity (By similarity). Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta-hexosaminidase A for cleavage of N-acetyl-D-galactosamine and conversion to GM3. [UniProt] |
| 细胞定位 | Lysosome. [UniProt] |
| 预测分子量 | 21 kDa |
| 翻译后修饰 | The serines in positions 32 and 33 are absent in 80% of the sequenced protein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
-
ARG58933 anti-GM2A antibody WB image
Western blot: HeLa cell lysate stained with ARG58933 anti-GM2A antibody at 0.2 - 1 µg/ml dilution.
