ARG55842
anti-GLS2 antibody
anti-GLS2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GLS2 |
|---|---|
| 反应物种 | Hu, Ms |
| 预测物种 | Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GLS2 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide corresponding to aa. 498-524 (C-terminus) of Human GLS2. |
| 偶联标记 | Un-conjugated |
| 別名 | L-glutamine amidohydrolase; LGA; EC 3.5.1.2; Glutaminase liver isoform, mitochondrial; GA; hLGA; GLS; L-glutaminase |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Human brain |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q571F8 Mouse Glutaminase liver isoform, mitochondrial Swiss-port # Q9UI32 Human Glutaminase liver isoform, mitochondrial |
|---|---|
| 基因名称 | GLS2 |
| 全名 | glutaminase 2 (liver, mitochondrial) |
| 背景介绍 | The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. Originally thought to be liver-specific, this protein has been found in other tissues as well. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
| 生物功能 | Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. [UniProt] |
| 细胞定位 | Mitochondrion. |
| 预测分子量 | 66 kDa |
检测图片 (2) Click the Picture to Zoom In
-
ARG55842 anti-GLS2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human hepatocarcinoma stained with ARG55842 anti-GLS2 antibody.
-
ARG55842 anti-GLS2 antibody WB image
Western blot: 35 µg of Human brain lysate stained with ARG55842 anti-GLS2 antibody at 1:1000 dilution.
