ARG58881
anti-GLDC antibody
anti-GLDC antibody for ICC/IF,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GLDC |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GLDC |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 36-290 of Human GLDC (NP_000161.2). |
| 偶联标记 | Un-conjugated |
| 別名 | GCE; GCSP; HYGN1; Glycine dehydrogenase (decarboxylating), mitochondrial; EC 1.4.4.2; Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring) |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| 阳性对照 | DU145 | ||||||||
| 实际分子量 | 113 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P23378 Human Glycine dehydrogenase (decarboxylating), mitochondrial Swiss-port # Q91W43 Mouse Glycine dehydrogenase (decarboxylating), mitochondrial |
|---|---|
| 基因名称 | GLDC |
| 全名 | glycine dehydrogenase (decarboxylating) |
| 背景介绍 | Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010] |
| 生物功能 | The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH). [UniProt] |
| 细胞定位 | Mitochondrion,. [UniProt] |
| 预测分子量 | 113 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58881 anti-GLDC antibody WB image
Western blot: 25 µg of DU145 cell lysate stained with ARG58881 anti-GLDC antibody at 1:1000 dilution.
