概述

产品描述	Rabbit Polyclonal antibody recognizes GFER
反应物种	Hu, Rat
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	GFER
抗原物种	Human
抗原	KLH-conjugated synthetic peptide corresponding to aa. 67-94 of Human GFER.
偶联标记	Un-conjugated
別名	Augmenter of liver regeneration; FAD-linked sulfhydryl oxidase ALR; HPO1; HSS; HPO2; HPO; ERV1; EC 1.8.3.2; Hepatopoietin; hERV1; ALR; HERV1

应用说明

应用建议	应用 推荐稀释比 WB 1:1000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	U251

属性

形式	Liquid
纯化	Purification with Protein A and immunogen peptide.
缓冲液	PBS and 0.09% (W/V) Sodium azide.
抗菌剂	0.09% (W/V) Sodium azide.
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 2671 Human GFER GeneID: 27100 Rat GFER Swiss-port # P55789 Human FAD-linked sulfhydryl oxidase ALR Swiss-port # Q63042 Rat FAD-linked sulfhydryl oxidase ALR
基因名称	GFER
全名	growth factor, augmenter of liver regeneration
背景介绍	The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
生物功能	Isoform 1: FAD-dependent sulfhydryl oxidase that regenerates the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4/MIA40, while GFER/ERV1 becomes re-oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2: May act as an autocrine hepatotrophic growth factor promoting liver regeneration. [UniProt]
细胞定位	Isoform 1: Mitochondrion intermembrane space. Mitochondrion; Isoform 2: Cytoplasm. Secreted. [UniProt]
预测分子量	23 kDa

检测图片 (1) Click the Picture to Zoom In