ARG41622
anti-GATA2 + GATA3 antibody
anti-GATA2 + GATA3 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Immunoprecipitation,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GATA2 + GATA3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GATA2 + GATA3 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human GATA2/3. |
| 偶联标记 | Un-conjugated |
| 別名 | GATA2: DCML; GATA-binding protein 2; NFE1B; IMD21; Endothelial transcription factor GATA-2; MONOMAC GATA3: HDR; HDRS |
应用说明
| 应用建议 |
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| 阳性对照 | K562 | ||||||||||
| 实际分子量 | ~ 50 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 基因名称 | GATA2; GATA3 |
|---|---|
| 全名 | GATA binding protein 2; GATA binding protein 3 |
| 背景介绍 | GATA2: This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] GATA3: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009] |
| 生物功能 | GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. [UniProt] GATA3: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. |
| 细胞定位 | GATA2 and GATA3: Nucleus. [UniProt] |
| 预测分子量 | GATA2: 50.5 kDa GATA3: 48 kDa |
检测图片 (3) Click the Picture to Zoom In
-
ARG41622 anti-GATA2 + GATA3 antibody ICC/IF image
Immunofluorescence: K562 cells stained with ARG41622 anti-GATA2 + GATA3 antibody.
-
ARG41622 anti-GATA2 + GATA3 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse kidney tissue stained with ARG41622 anti-GATA2 + GATA3 antibody.
-
ARG41622 anti-GATA2 + GATA3 antibody WB image
Western blot: K562 cell lysate stained with ARG41622 anti-GATA2 + GATA3 antibody.
