ARG52307
anti-GAT1 / GABA Transporter 1 antibody
anti-GAT1 / GABA Transporter 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Rat
Neuroscience antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GAT1/GABA Transporter 1 |
|---|---|
| 反应物种 | Rat |
| 预测物种 | Ms |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GAT1 / GABA Transporter 1 |
| 抗原物种 | Rat |
| 抗原 | Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | Solute carrier family 6 member 1; GAT-1; GAT1; Sodium- and chloride-dependent GABA transporter 1; MAE; GABATHG; GABATR |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for the ~67k GAT-1 protein. Immunolabeling is blocked by the peptide used as antigen. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P23978 Rat Sodium- and chloride-dependent GABA transporter 1 |
|---|---|
| 基因名称 | SLC6A1 |
| 全名 | solute carrier family 6 (neurotransmitter transporter), member 1 |
| 背景介绍 | Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl− channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by highaffinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003). |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 67 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG52307 anti-GAT1 / GABA Transporter 1 antibody WB image
Western blot: Rat hippocampal homogenate showing specific immunolabeling of the ~67 kDa GAT1 protein stained with ARG52307 anti-GAT1 / GABA Transporter 1 antibody.
