ARG40855
anti-GAD2 / GAD65 antibody
anti-GAD2 / GAD65 antibody for Western blot and Human,Rat
概述
| 产品描述 | Mouse Monoclonal antibody recognizes GAD2 / GAD65 |
|---|---|
| 反应物种 | Hu, Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG2b |
| 靶点名称 | GAD2 / GAD65 |
| 抗原物种 | Human |
| 抗原 | Purified recombinant Human GAD2 protein fragments. |
| 偶联标记 | Un-conjugated |
| 別名 | Glutamate decarboxylase 65 kDa isoform; EC 4.1.1.15; GAD65; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 2 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.4), 0.03% Proclin 300 and 50% Glycerol. |
| 抗菌剂 | 0.03% Proclin 300 |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | GAD2 |
| 全名 | glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) |
| 背景介绍 | This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008] |
| 生物功能 | Catalyzes the production of GABA. [UniProt] |
| 细胞定位 | Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters. [UniProt] |
| 预测分子量 | 65 kDa |
| 翻译后修饰 | Phosphorylated; which does not affect kinetic parameters or subcellular location. Palmitoylated; which is required for presynaptic clustering. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG40855 anti-GAD2 / GAD65 antibody WB image
Western blot: Rat hippocampus lysate stained with ARG40855 anti-GAD2 / GAD65 antibody at 1:1000 dilution.
