概述

产品描述	Rabbit Polyclonal antibody recognizes GABARAPL2
反应物种	Hu, Ms, Rat
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	GABARAPL2
抗原物种	Human
抗原	Synthetic peptide of Human GABARAPL2.
偶联标记	Un-conjugated
別名	A; Gamma-aminobutyric acid receptor-associated protein-like 2; GATE16; GATE-16; MAP1 light chain 3-related protein; General protein transport factor p16; GEF2; Ganglioside expression factor 2; ATG8; Golgi-associated ATPase enhancer of 16 kDa; ATG8C; GEF-2; GABA

应用说明

应用建议	应用 推荐稀释比 WB 1:500 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	HeLa
实际分子量	~ 15 kDa

属性

形式	Liquid
纯化	Affinity purified.
缓冲液	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 11345 Human GABARAPL2 GeneID: 64670 Rat GABARAPL2 GeneID: 93739 Mouse GABARAPL2 Swiss-port # P60520 Human Gamma-aminobutyric acid receptor-associated protein-like 2 Swiss-port # P60521 Mouse Gamma-aminobutyric acid receptor-associated protein-like 2 Swiss-port # P60522 Rat Gamma-aminobutyric acid receptor-associated protein-like 2 More
基因名称	GABARAPL2
全名	GABA(A) receptor-associated protein like 2
生物功能	Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. [UniProt]
细胞定位	Golgi apparatus. Cytoplasmic vesicle, autophagosome. [UniProt]
预测分子量	14 kDa
翻译后修饰	The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAPL2-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAPL2-II. ATG4B also mediates the delipidation required for GABARAPL1 recycling when autophagosomes fuse with lysosomes. The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine. [UniProt]

检测图片 (1) Click the Picture to Zoom In