ARG52304
anti-GABAB Receptor 2 phospho (Ser783) antibody
anti-GABAB Receptor 2 phospho (Ser783) antibody for ICC/IF,Western blot and Rat
Neuroscience antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GABAB Receptor 2 phospho (Ser783) |
|---|---|
| 反应物种 | Rat |
| 预测物种 | Hu, Ms, Bov, Chk, Dog, NHuPrm |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GABAB Receptor 2 |
| 抗原物种 | Rat |
| 抗原 | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser783 conjugated to KLH |
| 偶联标记 | Un-conjugated |
| 別名 | HRIHFB2099; GABA-B receptor 2; GABA-B-R2; GPRC3B; GABA-BR2; G-protein coupled receptor 51; GPR51; GABABR2; Gamma-aminobutyric acid type B receptor subunit 2; HG20; Gb2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | Specific for ~102k GABAB R2 phosphorylated at Ser783. Immunolabeling of the GABAB R2 band is completely blocked by λ-phosphatase treatment. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity Purified |
| 缓冲液 | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| 稳定剂 | 0.1 mg/ml BSA, 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # O88871 Rat Gamma-aminobutyric acid type B receptor subunit 2 |
|---|---|
| 基因名称 | GABBR2 |
| 全名 | gamma-aminobutyric acid (GABA) B receptor 2 |
| 背景介绍 | Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABAB receptors and phosphorylates S783 in the cytoplasmic tail of the R2 subunit and that S783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of S783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007). |
| 研究领域 | Neuroscience antibody |
| 预测分子量 | 106 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG52304 anti-GABAB Receptor 2 phospho (Ser783) antibody WB image
Western blot: Rat synaptic membrane showing specific immunolabeling of the ~102 k GABAB R2 protein phosphorylated at Ser783 (control) stained with ARG52304 anti-GABAB Receptor 2 phospho (Ser783) antibody. The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase).
