ARG22236
anti-GABAA Receptor alpha 1 antibody [S95-35]
anti-GABAA Receptor alpha 1 antibody [S95-35] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Mouse Monoclonal antibody [S95-35] recognizes GABAA Receptor alpha 1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 特异性 | Detects ~55kDa. No cross-reactivity against GABA-A-R-Alpha 2 or -Alpha3. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | S95-35 |
| 同位型 | IgG2a |
| 靶点名称 | GABAA Receptor alpha 1 |
| 抗原物种 | Human |
| 抗原 | Fusion protein around aa. 355-394 of Human GABAA Receptor alpha 1 |
| 偶联标记 | Un-conjugated |
| 別名 | A; EJM; EIEE19; EJM5; Gamma-aminobutyric acid receptor subunit alpha-1; ECA4; GABA |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.09% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | Gabra1 |
| 全名 | gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 |
| 背景介绍 | This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). [UniProt] |
| 细胞定位 | Cell Junction, Cell membrane, postsynaptic cell membrane, Synapse |
| 预测分子量 | 52 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG22236 anti-GABAA Receptor alpha 1 antibody [S95-35] WB image
Western blot: Human cell line lysates stained with ARG22236 anti-GABAA Receptor alpha 1 antibody [S95-35] at 1:1000 dilution.
