ARG40697
anti-GABAA Receptor alpha 1 antibody
anti-GABAA Receptor alpha 1 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes GABAA Receptor alpha 1 |
|---|---|
| 反应物种 | Hu, Rat |
| 预测物种 | Hm |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | GABAA Receptor alpha 1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 440-456 of Human GABAA Receptor alpha 1. (ATYLNREPQLKAPTPHQ) |
| 偶联标记 | Un-conjugated |
| 別名 | A; EJM; EIEE19; EJM5; Gamma-aminobutyric acid receptor subunit alpha-1; ECA4; GABA |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P14867 Human Gamma-aminobutyric acid receptor subunit alpha-1 Swiss-port # P62813 Rat Gamma-aminobutyric acid receptor subunit alpha-1 |
|---|---|
| 基因名称 | GABRA1 |
| 全名 | gamma-aminobutyric acid (GABA) A receptor, alpha 1 |
| 背景介绍 | This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). [UniProt] |
| 细胞定位 | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. [UniProt] |
| 预测分子量 | 52 kDa |
检测图片 (3) Click the Picture to Zoom In
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ARG40697 anti-GABAA Receptor alpha 1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat brain tissue stained with ARG40697 anti-GABAA Receptor alpha 1 antibody.
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ARG40697 anti-GABAA Receptor alpha 1 antibody WB image
Western blot: Rat brain lysates (both lanes) stained with ARG40697 anti-GABAA Receptor alpha 1 antibody.
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ARG40697 anti-GABAA Receptor alpha 1 antibody WB image
Western blot: 50 µg of sample under reducing conditions. HeLa and U-87MG whole cell lysates stained with ARG40697 anti-GABAA Receptor alpha 1 antibody at 0.5 µg/ml dilution, overnight at 4°C.
