ARG56858
anti-Filamin C antibody
anti-Filamin C antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Filamin C |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Cow, Dog, Gpig, Hrs, Rb, Zfsh |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Filamin C |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the N-terminus of Human Filamin C. (VGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDDKGDGSCDVRYWPTEP) |
| 偶联标记 | Un-conjugated |
| 別名 | ABP-280; FLNc; FLN2; Filamin-C; Gamma-filamin; ABP-280-like protein; ABPL; MPD4; Actin-binding-like protein; FLN-C; ABP280A; Filamin-2; MFM5; ABPA; ABP-L |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 whole cell |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS, 0.09% (w/v) Sodium azide and 2% Sucrose. |
| 抗菌剂 | 0.09% (w/v) Sodium azide |
| 稳定剂 | 2% Sucrose |
| 浓度 | 0.5 - 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FLNC |
| 全名 | filamin C, gamma |
| 背景介绍 | This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. [UniProt] |
| 预测分子量 | 291 kDa |
| 翻译后修饰 | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
检测图片 (1) Click the Picture to Zoom In
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ARG56858 anti-Filamin C antibody WB image
Western blot: HepG2 whole cell lysate stained with ARG56858 anti-Filamin C antibody at 1.0 µg/ml dilution.
