ARG46161
anti-Fibulin 3 antibody
anti-Fibulin 3 antibody for Western blot,ICC/IF and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Fibulin 3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Fibulin 3 |
| 抗原物种 | Human |
| 抗原 | A 19 amino acid synthetic peptide within aa. 410 - 460 of human Fibulin 3. |
| 偶联标记 | Un-conjugated |
| 別名 | EFEMP1; Fibulin 3; DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FIBL-3; EGF-containing fibulin-like extracellular matrix protein 1; Extracellular protein S1-5 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 实际分子量 | 47 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purified |
| 缓冲液 | PBS and 0.02% Sodium azide. |
| 抗菌剂 | 0.02% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -211°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q12805 Human EGF-containing fibulin-like extracellular matrix protein 1 Swiss-port # Q8BPB5 Mouse EGF-containing fibulin-like extracellular matrix protein 1 |
|---|---|
| 基因名称 | EFEMP1 |
| 全名 | EGF-containing fibulin-like extracellular matrix protein 1 |
| 背景介绍 | This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009] |
| 生物功能 | Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. [UniProt] |
| 细胞定位 | Extracellular matrix. [UniProt] |
| 预测分子量 | 52 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein. [UniProt] |
