ARG58647
anti-Fes antibody
anti-Fes antibody for Western blot and Mouse
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes Fes |
|---|---|
| 反应物种 | Ms |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | Fes |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 120-420 of Human Fes (NP_001137256.1). |
| 偶联标记 | Un-conjugated |
| 別名 | p93c-fes; Tyrosine-protein kinase Fes/Fps; Feline sarcoma/Fujinami avian sarcoma oncogene homolog; Proto-oncogene c-Fps; FPS; EC 2.7.10.2; Proto-oncogene c-Fes |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse brain | ||||
| 实际分子量 | 98 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FES |
| 全名 | FES proto-oncogene, tyrosine kinase |
| 背景介绍 | This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009] |
| 生物功能 | Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. [UniProt] |
| 细胞定位 | Cytoplasm, cytosol, Cytoplasm, cytoskeleton, Cell membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus, Cell junction, focal adhesion. [UniProt] |
| 预测分子量 | 93 kDa |
| 翻译后修饰 | Autophosphorylated on Tyr-713. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58647 anti-Fes antibody WB image
Western blot: 25 µg of Mouse brain lysate stained with ARG58647 anti-Fes antibody at 1:1000 dilution.
