ARG62486
anti-Factor XIIIa antibody [AC-1A1]
anti-Factor XIIIa antibody [AC-1A1] for ELISA,Flow cytometry,ICC/IF,IHC-Frozen sections,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cell Biology and Cellular Response antibody; Controls and Markers antibody
概述
| 产品描述 | Mouse Monoclonal antibody [AC-1A1] recognizes Factor XIIIa |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, WB |
| 特异性 | This antibody is specific to 160 kDa protein known as Factor XIIIA. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | AC-1A1 |
| 同位型 | IgG1, kappa |
| 靶点名称 | Factor XIIIa |
| 抗原物种 | Human |
| 抗原 | Recombinant human protein corresponding to A-subunit of coagulation Factor XIII |
| 偶联标记 | Un-conjugated |
| 別名 | Coagulation factor XIIIa; F13A; Protein-glutamine gamma-glutamyltransferase A chain; Coagulation factor XIII A chain; Transglutaminase A chain; EC 2.3.2.13 |
应用说明
| 应用说明 | IHC-Fr: 1/25 - 1/50 FACS: 1µg for 106 cells * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
|---|
属性
| 形式 | Liquid |
|---|---|
| 纯化 | IgG purified |
| 缓冲液 | PBS, 1% BSA and 0.05% Sodium azide |
| 抗菌剂 | 0.05% Sodium azide |
| 稳定剂 | 1% BSA |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | F13A1 |
| 全名 | coagulation factor XIII, A1 polypeptide |
| 背景介绍 | This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008] |
| 生物功能 | Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. [UniProt] |
| 细胞定位 | Cytoplasm. Secreted |
| 研究领域 | Cell Biology and Cellular Response antibody; Controls and Markers antibody |
| 预测分子量 | 83 kDa |
| 翻译后修饰 | The activation peptide is released by thrombin. |
克隆号文献
Regulation of gene expression by PI3K in mouse growth plate chondrocytes.
WB, IHC-P / Mouse
Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.
WB, ICC/IF / Mouse
Plaque-like CD34-positive dermal fibroma (medallion-like dermal dendrocyte hamartoma): clinicopathologic, immunohistochemical, and molecular analysis of 5 cases emphasizing its distinction from superficial, plaque-like dermatofibrosarcoma protuberans.
IHC / Human
Fibrofolliculoma/trichodiscoma and fibrous papule (perifollicular fibroma/angiofibroma): a revaluation of the histopathological and immunohistochemical features.
IHC-P / Human
Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation.
ICC/IF / Human
Expression and localization of plasma transglutaminase factor XIIIA in bone.
WB / Human
