ARG22573
anti-Factor VIII antibody [RFF-VIIIC/8]
anti-Factor VIII antibody [RFF-VIIIC/8] for ELISA,Radioimmunoassay,Western blot and Human,Pig
概述
| 产品描述 | Mouse Monoclonal antibody [RFF-VIIIC/8] recognizes Factor VIII |
|---|---|
| 反应物种 | Hu, Pig |
| 不反应物种 | Ms, Rat, Dog |
| 应用 | ELISA, RIA, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | RFF-VIIIC/8 |
| 同位型 | IgG1 |
| 靶点名称 | Factor VIII |
| 抗原物种 | Human |
| 抗原 | Affinity purified human Factor VIII. |
| 偶联标记 | Un-conjugated |
| 別名 | AHF; Antihemophilic factor; Coagulation factor VIII; HEMA; F8B; F8C; Procoagulant component; FVIII; DXS1253E |
应用说明
| 应用建议 |
|
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% Sodium azide |
| 抗菌剂 | 0.09% Sodium azide |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | F8 |
| 全名 | coagulation factor VIII, procoagulant component |
| 背景介绍 | This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008] |
| 生物功能 | Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. [UniProt] |
| 预测分子量 | 267 kDa |
| 翻译后修饰 | Sulfation on Tyr-1699 is essential for binding vWF. |
检测图片 (1) Click the Picture to Zoom In
-
ARG22573 anti-Factor VIII antibody [RFF-VIIIC/8] ELISA image
ELISA: Titration curve of ARG22573 anti-Factor VIII antibody [RFF-VIIIC/8]. Antigen: Recombinant Factor VIII.
