ARG42136
anti-FUT2 antibody
anti-FUT2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Goat Polyclonal antibody recognizes FUT2 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FUT2 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide around the internal region of Human FUT2. (C-HVQQRLAKIQAMWE) (NP_000502.4) |
| 偶联标记 | Un-conjugated |
| 別名 | Se2; B12QTL1; EC 2.4.1.69; 1,2; Fucosyltransferase 2; SEC2; Se; Galactoside 2-alpha-L-fucosyltransferase 2; Alpha; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2; Secretor factor; Secretor blood group alpha-2-fucosyltransferase; sej; SE; SE2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | WB: Recommend incubate at RT for 1h. IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
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| 阳性对照 | Human liver | ||||||
| 实际分子量 | ~ 37 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q10981 Human Galactoside 2-alpha-L-fucosyltransferase 2 |
|---|---|
| 基因名称 | FUT2 |
| 全名 | fucosyltransferase 2 (secretor status included) |
| 背景介绍 | The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). [UniProt] |
| 细胞定位 | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. [UniProt] |
| 预测分子量 | 39 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG42136 anti-FUT2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human placenta tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG42136 anti-FUT2 antibody at 5 µg/ml dilution followed by AP-staining.
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ARG42136 anti-FUT2 antibody WB image
Western blot: 35 µg of Human liver lysate (in RIPA buffer) stained with ARG42136 anti-FUT2 antibody at 1 µg/ml dilution and incubated at RT for 1 hour.
