ARG58723
anti-FRZB antibody
anti-FRZB antibody for Western blot and Mouse,Rat
参考文献1
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FRZB |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FRZB |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 166-325 of Human FRZB (NP_001454.2). |
| 偶联标记 | Un-conjugated |
| 別名 | FRP-3; Frizzled-related protein 1; FRE; hFIZ; OS1; FrzB-1; FRZB-PEN; FRZB-1; Fritz; Secreted frizzled-related protein 3; SFRP3; FRZB1; Frezzled; FRITZ; FZRB; SRFP3; sFRP-3 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Mouse skeletal muscle | ||||
| 实际分子量 | 38 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P97401 Mouse Secreted frizzled-related protein 3 |
|---|---|
| 基因名称 | FRZB |
| 全名 | frizzled-related protein |
| 背景介绍 | The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010] |
| 生物功能 | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 36 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG58723 anti-FRZB antibody ICC/IF image
Immunofluorescence: Mouse knee joints stained with ARG58723 anti-FRZB antibody.
From An X et al. Exp Mol Med. (2024), doi: 10.1038/s12276-023-01135-5, Fig. 5. F.
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ARG58723 anti-FRZB antibody WB image
Western blot: 25 µg of Mouse skeletal muscle lysate stained with ARG58723 anti-FRZB antibody at 1:1000 dilution.
文献引用
WTAP-mediated m6A modification of FRZB triggers the inflammatory response via the Wnt signaling pathway in osteoarthritis
ICC/IF / Mouse
