ARG42341
anti-FOLR2 antibody [EM-35] (PE)
anti-FOLR2 antibody [EM-35] (PE) for Flow cytometry and Human
概述
| 产品描述 | PE-conjugated Mouse Monoclonal antibody [EM-35] recognizes FOLR2 |
|---|---|
| 反应物种 | Hu |
| 不反应物种 | Ms |
| 应用 | FACS |
| 特异性 | The mouse monoclonal antibody EM-35 recognizes an extracellular epitope on FOLR2, a 30-40 kDa cell surface protein serving as a receptor for folic acid. |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | EM-35 |
| 同位型 | IgG1 |
| 靶点名称 | FOLR2 |
| 抗原物种 | Human |
| 抗原 | BW5147 alpha, beta cells. |
| 偶联标记 | PE |
| 別名 | Folate receptor 2; BETA-HFR; FBP; Folate receptor beta; Folate receptor, fetal/placental; FBP/PL-1; FR-beta; FR-P3; Placental folate-binding protein; FR-BETA |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified |
| 缓冲液 | PBS and 15 mM Sodium azide. |
| 抗菌剂 | 15 mM Sodium azide |
| 浓度 | 0.1 mg/ml |
| 存放说明 | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FOLR2 |
| 全名 | folate receptor 2 (fetal) |
| 背景介绍 | The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
| 生物功能 | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. [UniProt] |
| 细胞定位 | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. [UniProt] |
| 预测分子量 | 29 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG42341 anti-FOLR2 antibody [EM-35] (PE) FACS image
Flow Cytometry: FOLR2 transfectants (red) stained with ARG42341 anti-FOLR2 antibody [EM-35] (PE), compared with blank (blue).
