ARG58752
anti-FNTA antibody
anti-FNTA antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FNTA |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Bov |
| 应用 | IHC-P |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FNTA |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide between aa. 330-360 of Human FNTA. |
| 偶联标记 | Un-conjugated |
| 別名 | Type I protein geranyl-geranyltransferase subunit alpha; PTAR2; FTase-alpha; GGTase-I-alpha; PGGT1A; FPTA; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; CAAX farnesyltransferase subunit alpha; EC 2.5.1.58; EC 2.5.1.59; Ras proteins prenyltransferase subunit alpha |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein G. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P49354 Human Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
|---|---|
| 基因名称 | FNTA |
| 全名 | farnesyltransferase, CAAX box, alpha |
| 背景介绍 | Prenyltransferases can attach either a farnesyl group or a geranylgeranyl group in thioether linkage to the cysteine residue of proteins with a C-terminal CAAX box. CAAX geranylgeranyltransferase and CAAX farnesyltransferase are heterodimers that share the same alpha subunit but have different beta subunits. This gene encodes the alpha subunit of these transferases. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 11 and 13. [provided by RefSeq, May 2010] |
| 生物功能 | Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. [UniProt] |
| 预测分子量 | 44 kDa |
| 翻译后修饰 | Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity). [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58752 anti-FNTA antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human cancer tissue stained with ARG58752 anti-FNTA antibody.
