ARG58727
anti-FKBP3 / FKBP25 antibody
anti-FKBP3 / FKBP25 antibody for Immunoprecipitation,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FKBP3 / FKBP25 |
|---|---|
| 反应物种 | Hu |
| 应用 | IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FKBP3 / FKBP25 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-224 of Human FKBP3 (NP_002004.1). |
| 偶联标记 | Un-conjugated |
| 別名 | PPIase FKBP3; FK506-binding protein 3; Rotamase; FKBP25; FKBP-25; FKBP-3; EC 5.2.1.8; PPIase; 25 kDa FKBP; 25 kDa FK506-binding protein; Rapamycin-selective 25 kDa immunophilin; Peptidyl-prolyl cis-trans isomerase FKBP3; Immunophilin FKBP25 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | BT474 | ||||||
| 实际分子量 | 30 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q00688 Human Peptidyl-prolyl cis-trans isomerase FKBP3 |
|---|---|
| 基因名称 | FKBP3 |
| 全名 | FK506 binding protein 3, 25kDa |
| 背景介绍 | The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008] |
| 生物功能 | FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 25 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG58727 anti-FKBP3 / FKBP25 antibody WB image
Western blot: 25 µg of BT474 cell lysate stained with ARG58727 anti-FKBP3 / FKBP25 antibody at 1:1000 dilution.
