ARG45067
anti-FHOD1 antibody [M352]
anti-FHOD1 antibody [M352] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [M352] recognizes FHOD1 |
|---|---|
| 反应物种 | Hu |
| 应用 | IHC-P, WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | M352 |
| 同位型 | IgG1 |
| 靶点名称 | FHOD1 |
| 抗原物种 | Human |
| 抗原 | FHOD1 recombinant protein that included the full length human FHOD1 sequence. This sequence has 50% homology to human FHOD3, and low homology to other formin family members. |
| 偶联标记 | Un-conjugated |
| 別名 | FHOD1; Formin Homology 2 Domain Containing 1; FHOS; Formin Homolog Overexpressed In Spleen 1; FH1/FH2 Domain-Containing Protein 1; Formin Homology 2 Domain-Containing Protein 1; FHOS1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A Purified. |
| 缓冲液 | PBS, 0.05% NaN3, 50% Glycerol and 0.1 % BSA. |
| 稳定剂 | 50% Glycerol and 0.1 % BSA |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q9Y613 Human FH1/FH2 domain-containing protein 1 |
|---|---|
| 基因名称 | FHOD1 |
| 全名 | Formin Homology 2 Domain Containing 1 |
| 背景介绍 | This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| 生物功能 | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. [Uniprot] |
| 细胞定位 | Cell projection, Cytoplasm, Cytoskeleton. [Uniprot] |
| 预测分子量 | 127 kDa |
| 翻译后修饰 | Phosphoprotein. [Uniprot] |
