ARG57541
anti-FHL2 antibody [21D11]
anti-FHL2 antibody [21D11] for Western blot and Human
概述
| 产品描述 | Mouse Monoclonal antibody [21D11] recognizes FHL2 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 克隆号 | 21D11 |
| 同位型 | IgG1, kappa |
| 靶点名称 | FHL2 |
| 抗原物种 | Human |
| 抗原 | Recombinant Human FHL2 (aa. 1-279) purified from E. coli. |
| 偶联标记 | Un-conjugated |
| 別名 | AAG11; Four and a half LIM domains protein 2; SLIM-3; FHL-2; LIM domain protein DRAL; DRAL; SLIM3; Skeletal muscle LIM-protein 3 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A. |
| 缓冲液 | PBS (pH 7.4), 0.02% Sodium azide and 10% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 10% Glycerol |
| 浓度 | 1 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q14192 Human Four and a half LIM domains protein 2 |
|---|---|
| 基因名称 | FHL2 |
| 全名 | four and a half LIM domains 2 |
| 背景介绍 | This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Aug 2011] |
| 生物功能 | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. [UniProt] |
| 预测分子量 | 32 kDa |
检测图片 (1) Click the Picture to Zoom In
-
ARG57541 anti-FHL2 antibody [21D11] WB image
Western blot: 40 µg of HeLa, A549, MCF7, SK-OV-3 and HT1080 cell lysates stained with ARG57541 anti-FHL2 antibody [21D11] at 1:1000 dilution.
