ARG59211
anti-FGF19 antibody
anti-FGF19 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FGF19 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Mk |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FGF19 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide corresponding to aa. 124-140 of Human FGF19. (EEIRPDGYNVYRSEKHR) |
| 偶联标记 | Un-conjugated |
| 別名 | Fibroblast growth factor 19; FGF-19 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: By heat mediation. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| 抗菌剂 | 0.05% Thimerosal and 0.05% Sodium azide |
| 稳定剂 | 5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FGF19 |
| 全名 | fibroblast growth factor 19 |
| 背景介绍 | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008] |
| 生物功能 | Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4. [UniProt] |
| 细胞定位 | Secreted. [UniProt] |
| 预测分子量 | 24 kDa |
检测图片 (2) Click the Picture to Zoom In
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ARG59211 anti-FGF19 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human gallbladder cancer stained with ARG59211 anti-FGF19 antibody.
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ARG59211 anti-FGF19 antibody WB image
Western blot: 40 µg of U87 and SMMC-7721 whole cell lysates stained with ARG59211 anti-FGF19 antibody at 0.5 µg/ml dilution.
