ARG41915
anti-FBXO45 antibody
anti-FBXO45 antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FBXO45 |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FBXO45 |
| 抗原物种 | Human |
| 抗原 | KLH-conjugated synthetic peptide between aa. 83-115 of Human FBXO45. |
| 偶联标记 | Un-conjugated |
| 別名 | F-box/SPRY domain-containing protein 1; F-box only protein 45; Fbx45; hFbxo45 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HT-1080 | ||||
| 实际分子量 | ~ 30 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purification with Protein A and immunogen peptide. |
| 缓冲液 | PBS and 0.09% (W/V) Sodium azide. |
| 抗菌剂 | 0.09% (W/V) Sodium azide. |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # P0C2W1 Human F-box/SPRY domain-containing protein 1 |
|---|---|
| 基因名称 | FBXO45 |
| 全名 | F-box protein 45 |
| 背景介绍 | Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011] |
| 生物功能 | Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May controls synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. [UniProt] |
| 细胞定位 | Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, presynaptic cell membrane. [UniProt] |
| 预测分子量 | 31 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG41915 anti-FBXO45 antibody WB image
Western blot: 20 µg of HT-1080 whole cell lysate stained with ARG41915 anti-FBXO45 antibody at 1:2000 dilution.
