ARG55503
anti-FBXO32 antibody
anti-FBXO32 antibody for ICC/IF,Western blot and Human,Mouse
Cell Biology and Cellular Response antibody; Developmental Biology antibody
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FBXO32 |
|---|---|
| 反应物种 | Hu, Ms |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FBXO32 |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human FBXO32 |
| 偶联标记 | Un-conjugated |
| 別名 | Muscle atrophy F-box protein; Atrogin-1; F-box only protein 32; Fbx32; MAFbx |
应用说明
| 预测反应性说明 | Human, Rat | ||||||
|---|---|---|---|---|---|---|---|
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | Mouse heart |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FBXO32 |
| 全名 | F-box protein 32 |
| 背景介绍 | This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011] |
| 生物功能 | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. [UniProt] |
| 研究领域 | Cell Biology and Cellular Response antibody; Developmental Biology antibody |
| 预测分子量 | 42 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG55503 anti-FBXO32 antibody WB image
Western blot: Mouse heart lysate stained with ARG55503 anti-FBXO32 antibody.
