ARG42006
anti-FBLN5 / Fibulin 5 antibody
anti-FBLN5 / Fibulin 5 antibody for ICC/IF,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FBLN5 / Fibulin 5 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FBLN5 / Fibulin 5 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 199-448 of Human FBLN5 / Fibulin 5 (NP_006320.2). |
| 偶联标记 | Un-conjugated |
| 別名 | Urine p50 protein; FIBL-5; DANCE; Dance; ARMD3; EVEC; Developmental arteries and neural crest EGF-like protein; ARCL1A; Fibulin-5; UP50; ADCL2 |
应用说明
| 应用建议 |
|
||||||
|---|---|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | A549 | ||||||
| 实际分子量 | ~ 70 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FBLN5 |
| 全名 | fibulin 5 |
| 背景介绍 | The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008] |
| 生物功能 | Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. [UniProt] |
| 细胞定位 | Secreted. Secreted, extracellular space, extracellular matrix. Note=co-localizes with ELN in elastic fibers. [UniProt] |
| 预测分子量 | 50 kDa |
| 翻译后修饰 | N-glycosylated. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
-
ARG42006 anti-FBLN5 / Fibulin 5 antibody ICC/IF image
Immunofluorescence: L929 cells stained with ARG42006 anti-FBLN5 / Fibulin 5 antibody at 1:100 dilution.
-
ARG42006 anti-FBLN5 / Fibulin 5 antibody WB image
Western blot: 25 µg of A549 cell lysate stained with ARG42006 anti-FBLN5 / Fibulin 5 antibody at 1:1000 dilution.
