ARG58665
anti-FANCA antibody
anti-FANCA antibody for Western blot and Human
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FANCA |
|---|---|
| 反应物种 | Hu |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FANCA |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-275 of Human FANCA (NP_000126.2). |
| 偶联标记 | Un-conjugated |
| 別名 | FACA; Fanconi anemia group A protein; FA1; FA-H; FA; FAH; FAA; Protein FACA; FANCH |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HeLa | ||||
| 实际分子量 | 163 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FANCA |
| 全名 | Fanconi anemia, complementation group A |
| 背景介绍 | The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia. [provided by RefSeq, Jul 2008] |
| 生物功能 | DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. [UniProt] |
| 细胞定位 | Nucleus, Cytoplasm. [UniProt] |
| 预测分子量 | 163 kDa |
| 翻译后修饰 | Phosphorylation is required for the formation of the nuclear complex. Not phosphorylated in cells derived from groups A, B, C, E, F, G, and H. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58665 anti-FANCA antibody WB image
Western blot: 25 µg of HeLa cell lysate stained with ARG58665 anti-FANCA antibody at 1:1000 dilution.
