ARG59790
anti-FAIM3 antibody
anti-FAIM3 antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FAIM3 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FAIM3 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 18-251 of Human FAIM3 (NP_005440.1). |
| 偶联标记 | Un-conjugated |
| 別名 | FAIM3; IgM Fc fragment receptor; Fas apoptotic inhibitory molecule 3; TOSO; Regulator of Fas-induced apoptosis Toso |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | SW480 | ||||
| 实际分子量 | ~ 41 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | FCMR |
| 全名 | Fc fragment of IgM receptor |
| 背景介绍 | Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010] |
| 生物功能 | May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. [UniProt] |
| 细胞定位 | Isoform 1: Membrane; Single-pass membrane protein. Isoform 3: Secreted. Note=Detected in the serum. [UniProt] |
| 预测分子量 | 43 kDa |
检测图片 (1) Click the Picture to Zoom In
-
ARG59790 anti-FAIM3 antibody WB image
Western blot: 25 µg of SW480 cell lysate stained with ARG59790 anti-FAIM3 antibody at 1:1000 dilution.
