ARG43575
anti-FADD antibody
anti-FADD antibody for Flow cytometry,Immunoprecipitation,Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes FADD. |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | FACS, IP, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | FADD |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide derived from human FADD |
| 偶联标记 | Un-conjugated |
| Protein Full name | FAS-associated death domain protein |
| 別名 | GIG3; MORT1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | 50 mM Tris-Glycine (pH 7.4), 150 mM NaCl, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA. |
| 抗菌剂 | 0.01% Sodium azide |
| 稳定剂 | 40% Glycerol and 0.05% BSA |
| 浓度 | Batch dependent |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q61160 Mouse FAS-associated death domain protein |
|---|---|
| 基因名称 | FADD |
| 全名 | Fas (TNFRSF6)-associated via death domain |
| 背景介绍 | The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008] |
| 生物功能 | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. [UniProt] |
检测图片 (2) Click the Picture to Zoom In
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ARG43575 anti-FADD antibody WB image
Western blot: Rat brain stained with ARG43575 anti-FADD antibody.
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ARG43575 anti-FADD antibody WB image
Western blot: 3T3 stained with ARG43575 anti-FADD antibody.
