ARG43814
anti-F2RL1 antibody [22F95]
anti-F2RL1 antibody [22F95] for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit monoclonal antibody [22F95] recognizes F2RL1 |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | ICC/IF, IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Monoclonal |
| 克隆号 | 22F95 |
| 同位型 | IgG |
| 靶点名称 | F2RL1 |
| 抗原物种 | Human |
| 抗原 | Synthetic peptide of Human F2RL1. |
| 偶联标记 | Un-conjugated |
| Protein Full name | Proteinase-activated receptor 2 |
| 別名 | F2RL1, F2R Like Trypsin Receptor 1 , PAR2, GPR11, Coagulation Factor II (Thrombin) Receptor-Like 1, Proteinase-Activated Receptor 2, G-Protein Coupled Receptor 11, Thrombin Receptor-Like 1, Coagulation Factor II Receptor-Like 1, Proteinase-Activated Receptor-2 , Protease-Activated Receptor 2, PAR-2 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|---|---|---|---|
| 阳性对照 | K562 | ||||||||
| 实际分子量 | 52~60 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity chromatography purification |
| 缓冲液 | PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide, 50% Glycerol and 0.4 - 0.5 mg/ml BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol and 0.4 - 0.5 mg/ml BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | F2RL1 |
| 全名 | F2R Like Trypsin Receptor 1 |
| 背景介绍 | This gene encodes a member of the G-protein coupled receptor 1 family of proteins. The encoded cell surface receptor is activated through proteolytic cleavage of its extracellular amino terminus, resulting in a new amino terminus that acts as a tethered ligand that binds to an extracellular loop domain. Activation of the receptor has been shown to stimulate vascular smooth muscle relaxation, dilate blood vessels, increase blood flow, and lower blood pressure. This protein is also important in the inflammatory response, as well as innate and adaptive immunity. [provided by RefSeq, Jun 2016] |
| 生物功能 | Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3. [UniProt] |
| 细胞定位 | Cell membrane; Membrane |
| 预测分子量 | 44 kDa |
| 翻译后修饰 | N-glycosylated and sialylated.1 Multiple phosphorylated on serine and threonine residues in the cytoplasmic region upon receptor activation; required for receptor desensitization and recruitment of beta-arrestin.1 Monoubiquitinated by CBL at the plasma membrane and in early endosomes; not required for receptor endocytosis but for translocation to late endosomes or lysosomes. Deubiquitination involves STAMBP and USP8; required for lysosomal trafficking and receptor degradation. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG43814 anti-F2RL1 antibody [22F95] WB image
Western blot:K562 cell stained with ARG43814 anti-F2RL1 antibody [22F95] WB image.
