概述

产品描述	Rabbit Polyclonal antibody recognizes EphB4
反应物种	Hu, Ms
应用	WB
宿主	Rabbit
克隆	Polyclonal
同位型	IgG
靶点名称	EphB4
抗原物种	Human
抗原	Recombinant protein of Human EphB4.
偶联标记	Un-conjugated
別名	MYK1; EC 2.7.10.1; HTK; Tyrosine-protein kinase TYRO11; Hepatoma transmembrane kinase; Ephrin type-B receptor 4; TYRO11

应用说明

应用建议	应用 推荐稀释比 WB 1:200 - 1:2000
应用说明	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
阳性对照	Mouse liver

属性

形式	Liquid
纯化	Affinity purification with immunogen.
缓冲液	PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol.
抗菌剂	0.02% Sodium azide
稳定剂	50% Glycerol
存放说明	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
注意事项	For laboratory research only, not for drug, diagnostic or other use.

生物信息

数据库连接	GeneID: 13846 Mouse EPHB4 GeneID: 2050 Human EPHB4 Swiss-port # P54760 Human Ephrin type-B receptor 4 Swiss-port # P54761 Mouse Ephrin type-B receptor 4
基因名称	EPHB4
全名	EPH receptor B4
背景介绍	Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]
生物功能	Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. [UniProt]
预测分子量	108 kDa
翻译后修饰	Phosphorylated; autophosphorylation is stimulated by EFNB2.

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