ARG44657
anti-EphB4 antibody
anti-EphB4 antibody for Immunoprecipitation and Human
概述
| 产品描述 | Mouse Monoclonal antibody recognizes EphB4 |
|---|---|
| 反应物种 | Hu |
| 应用 | IP |
| 宿主 | Mouse |
| 克隆 | Monoclonal |
| 同位型 | IgG1 |
| 靶点名称 | EphB4 |
| 抗原物种 | Human |
| 偶联标记 | Un-conjugated |
| 別名 | EPHB4; EPH Receptor B4; Tyro11; HTK; Tyrosine-Protein Kinase TYRO11; Hepatoma Transmembrane Kinase; Ephrin Type-B Receptor 4; EC 2.7.10.1; MYK1; Tyrosine-Protein Kinase Receptor HTK; Ephrin Receptor EphB4; EC 2.7.10; CMAVM2; LMPHM7; TYRO11; EphB4; HFASD |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein A purification |
| 缓冲液 | PBS with 0.09% sodium azide |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | EPHB4 |
| 全名 | EPH Receptor B4 |
| 背景介绍 | Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008] |
| 生物功能 | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and blood vessel remodeling and permeability. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. [UniProt] |
| 细胞定位 | Cell membrane, Membrane. [UniProt] |
| 预测分子量 | 108 kDa |
| 翻译后修饰 | Disulfide bond, Glycoprotein, Phosphoprotein. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG44657 anti-EphB4 antibody IP image
Immunoprecipitation: MCF7 lysate immunoprecipitated with 2.5 µg of ARG44657 anti-EphB4 antibody.
