ARG45350
anti-EphA7 antibody [60]
anti-EphA7 antibody [60] for IHC-Formalin-fixed paraffin-embedded sections and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [60] recognizes EphA7 |
|---|---|
| 反应物种 | Ms |
| 应用 | IHC-P |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 60 |
| 同位型 | IgG1 |
| 靶点名称 | EphA7 |
| 抗原物种 | Mouse |
| 抗原 | Recombinant Mouse EphA7. |
| 偶联标记 | Un-conjugated |
| 別名 | EK11; hEK11; EPH homology kinase 3; EPH-like kinase 11; EHK3; EHK-3; Ephrin type-A receptor 7; HEK11; EC 2.7.10.1 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G/A chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | EPHA7 |
| 全名 | EPH receptor A7 |
| 背景介绍 | This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013] |
| 生物功能 | Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. [UniProt] |
| 细胞定位 | Cell membrane; Single-pass type I membrane protein. [UniProt] |
| 预测分子量 | 112 kDa |
| 翻译后修饰 | Phosphorylated. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45350 anti-EphA7 antibody [60] IHC-P image
Immunohistochemistry: Mouse kidney stained with ARG45350 anti-EphA7 antibody [60].
