ARG45348
anti-Endostatin antibody [3H11]
anti-Endostatin antibody [3H11] for IHC-Formalin-fixed paraffin-embedded sections and Mouse
概述
| 产品描述 | Rat Monoclonal antibody [3H11] recognizes Endostatin |
|---|---|
| 反应物种 | Ms |
| 应用 | IHC-P |
| 宿主 | Rat |
| 克隆 | Monoclonal |
| 克隆号 | 3H11 |
| 同位型 | IgG2 |
| 靶点名称 | Endostatin |
| 抗原物种 | Mouse |
| 抗原 | Recombinant Mouse Endostatin. |
| 偶联标记 | Un-conjugated |
| 別名 | KS; KNO; KNO1; Collagen alpha-1(XVIII) chain |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Protein G/A chromatography |
| 缓冲液 | PBS |
| 浓度 | 0.2 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | COL18A1 |
| 全名 | collagen, type XVIII, alpha 1 |
| 背景介绍 | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
| 生物功能 | Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. [UniProt] |
| 细胞定位 | Basement membrane; Extracellular matrix; Secreted. [UniProt] |
| 产品亮点 | Related products: Endostatin antibodies; Endostatin ELISA Kits; New ELISA data calculation tool: Simplify the ELISA analysis by GainData |
| 预测分子量 | 182 kDa |
| 翻译后修饰 | Disulfide bond; Glycoprotein; Hydroxylation; Phosphoprotein; Proteoglycan. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG45348 anti-Endostatin antibody [3H11] IHC-P image
Immunohistochemistry: Mouse lung stained with ARG45348 anti-Endostatin antibody [3H11].
