ARG67066

anti-EZH2 antibody [SQab30336]

anti-EZH2 antibody [SQab30336] for IHC-Formalin-fixed paraffin-embedded sections and Human

概述

产品描述 Recombinant Rabbit Monoclonal antibody [SQab30336] recognizes EZH2
反应物种 Hu
应用 IHC-P
宿主 Rabbit
克隆 Monoclonal
克隆号 SQab30336
靶点名称 EZH2
抗原物种 Human
抗原 Recombinant protein fragment of EZH2
偶联标记 Un-conjugated
Protein Full name EZH2
別名 EZH2 ; Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit; ENX-1; KMT6 ; KMT6A; Histone-Lysine N-Methyltransferase EZH2; Lysine N-Methyltransferase 6; Enhancer Of Zeste Homolog 2; EZH1; Enhancer Of Zeste (Drosophila) Homolog 2; Enhancer Of Zeste Homolog 2 (Drosophila) 2 EC 2.1.1.43'); EC 2.1.1.356; EC 2.1.1.43; EC 2.1.1; EZH2b; ENX1; WVS2; WVS

属性

形式 Liquid
纯化 Purification with Protein A.
缓冲液 PBS, 0.01% Sodium azide, 40% Glycerol and 0.05% BSA.
抗菌剂 0.01% Sodium azide
稳定剂 40% Glycerol and 0.05% BSA
存放说明 -20°C
注意事项 For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.

生物信息

数据库连接

GeneID: 2146 Human EZH2

Swiss-port # Q15910 Human Histone-lysine N-methyltransferase EZH2

基因名称 EZH2
全名 enhancer of zeste 2 polycomb repressive complex 2 subunit
背景介绍 This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
生物功能 Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2. [UniProt]
细胞定位 Nucleus. [UniProt]
预测分子量 85 kDa
翻译后修饰 Glycoprotein, Isopeptide bond, Phosphoprotein,Ubl conjugation. [UniProt]

检测图片 (1) Click the Picture to Zoom In

  • ARG67066 anti-EZH2 antibody [SQab30336] IHC-P image

    Immunohistochemistry: Human testis tissue stained with ARG67066 anti-EZH2 antibody [SQab30336] at 1:100 dilution.