ARG58680
anti-ETV6 / Tel antibody
anti-ETV6 / Tel antibody for Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes ETV6 / Tel |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | ETV6 / Tel |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-300 of Human ETV6 (NP_001978.1). |
| 偶联标记 | Un-conjugated |
| 別名 | TEL; TEL/ABL; Transcription factor ETV6; THC5; ETS-related protein Tel1; Tel; ETS translocation variant 6 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | HepG2 | ||||
| 实际分子量 | 53 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 | |
|---|---|
| 基因名称 | ETV6 |
| 全名 | ets variant 6 |
| 背景介绍 | This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008] |
| 生物功能 | Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation. [UniProt] |
| 细胞定位 | Nucleus. [UniProt] |
| 预测分子量 | 53 kDa |
| 翻译后修饰 | Phosphorylation of Ser-257 by MAPK14 (p38) inhibits ETV6 transcriptional repression. [UniProt] |
检测图片 (1) Click the Picture to Zoom In
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ARG58680 anti-ETV6 / Tel antibody WB image
Western blot: 25 µg of HepG2 cell lysate stained with ARG58680 anti-ETV6 / Tel antibody at 1:1000 dilution.
