ARG63540
anti-EPS8 antibody
anti-EPS8 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Cancer antibody; Signaling Transduction antibody
概述
| 产品描述 | Goat Polyclonal antibody recognizes EPS8 |
|---|---|
| 反应物种 | Hu |
| 预测物种 | Ms, Rat, Dog, Pig |
| 应用 | IHC-P |
| 宿主 | Goat |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | EPS8 |
| 抗原物种 | Human |
| 抗原 | C-SGVESFDEGSSH |
| 偶联标记 | Un-conjugated |
| 別名 | DFNB102; Epidermal growth factor receptor kinase substrate 8 |
应用说明
| 应用建议 |
|
||||
|---|---|---|---|---|---|
| 应用说明 | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Purified from goat serum by antigen affinity chromatography. |
| 缓冲液 | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 0.5% BSA |
| 浓度 | 0.5 mg/ml |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q12929 Human Epidermal growth factor receptor kinase substrate 8 |
|---|---|
| 背景介绍 | This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| 研究领域 | Cancer antibody; Signaling Transduction antibody |
| 预测分子量 | 92 kDa |
| 翻译后修饰 | Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during G2 phase, leading to its transient degradation and subsequent cell shape changes required to allow mitotic progression. Reappears at the midzone of dividing cells (By similarity). Phosphorylation at Ser-625 and Thr-629 by MAPK following BDNF treatment promotes removal from actin and filopodia formation (By similarity). Phosphorylated by several receptor tyrosine kinases. |
检测图片 (1) Click the Picture to Zoom In
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ARG63540 anti-EPS8 antibody IHC-P image
Immunohistochemistry: paraffin embedded Human Breast Carcinoma. (Steamed antigen retrieval with citrate buffer pH 6) stained with ARG63540 anti-EPS8 antibody at 5 µg/ml dilution followed by AP-staining.
