ARG59414
anti-EME1 antibody
anti-EME1 antibody for Western blot and Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes EME1 |
|---|---|
| 反应物种 | Ms, Rat |
| 应用 | WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | EME1 |
| 抗原物种 | Human |
| 抗原 | Recombinant fusion protein corresponding to aa. 1-320 of Human EME1 (NP_689676.2). |
| 偶联标记 | Un-conjugated |
| 別名 | MMS4 homolog; MMS4L; SLX2A; EC 3.1.22.-; Crossover junction endonuclease EME1; hMMS4 |
应用说明
| 应用建议 |
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|---|---|---|---|---|---|
| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| 阳性对照 | Rat thymus and Mouse thymus | ||||
| 实际分子量 | 63 kDa |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purified. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q8BJW7 Mouse Crossover junction endonuclease EME1 |
|---|---|
| 基因名称 | EME1 |
| 全名 | essential meiotic structure-specific endonuclease 1 |
| 背景介绍 | This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3'-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009] |
| 生物功能 | Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. [UniProt] |
| 细胞定位 | Nucleus, nucleolus. Note=Recruited to regions of DNA damage in S-phase cells. [UniProt] |
| 预测分子量 | 63 kDa |
检测图片 (1) Click the Picture to Zoom In
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ARG59414 anti-EME1 antibody WB image
Western blot: 25 µg of Rat thymus and Mouse thymus lysates stained with ARG59414 anti-EME1 antibody at 1:1000 dilution.
