ARG56295
anti-EMAP II antibody
anti-EMAP II antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
概述
| 产品描述 | Rabbit Polyclonal antibody recognizes EMAP II |
|---|---|
| 反应物种 | Hu, Ms, Rat |
| 应用 | IHC-P, WB |
| 宿主 | Rabbit |
| 克隆 | Polyclonal |
| 同位型 | IgG |
| 靶点名称 | EMAP II |
| 抗原物种 | Human |
| 抗原 | Recombinant protein of Human EMAP II |
| 偶联标记 | Un-conjugated |
| 別名 | Endothelial monocyte-activating polypeptide II; Multisynthase complex auxiliary component p43; Small inducible cytokine subfamily E member 1; EMAPII; EMAP-2; EMAP-II; SCYE1; EMAP2; p43; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; HLD3 |
应用说明
| 应用建议 |
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| 应用说明 | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| 阳性对照 | HepG2 |
属性
| 形式 | Liquid |
|---|---|
| 纯化 | Affinity purification with immunogen. |
| 缓冲液 | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| 抗菌剂 | 0.02% Sodium azide |
| 稳定剂 | 50% Glycerol |
| 存放说明 | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| 注意事项 | For laboratory research only, not for drug, diagnostic or other use. |
生物信息
| 数据库连接 |
Swiss-port # Q12904 Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 |
|---|---|
| 基因名称 | AIMP1 |
| 全名 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 |
| 背景介绍 | The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008] |
| 生物功能 | Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation. Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels. Promotes dermal fibroblast proliferation and wound repair. Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum. Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations. Induces maturation of dendritic cells and monocyte cell adhesion. Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7. [UniProt] |
| 预测分子量 | 34 kDa |
| 翻译后修饰 | Cleaved by caspase-7 in response to apoptosis to produce EMAP-II. |
检测图片 (2) Click the Picture to Zoom In
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ARG56295 anti-EMAP II antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat heart stained with ARG56295 anti-EMAP II antibody at 1:100 dilution.
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ARG56295 anti-EMAP II antibody WB image
Western blot: HepG2 cell lysate stained with ARG56295 anti-EMAP II antibody.
